COX Inhibitors
- Welcome to the
Rosacea Support Resource Pages
These pages hold in-progress web pages for the benefit of Rosacea Support Group members. Information provided herein is intended for informational purposes only and is not intended to replace medical advice offered by a physician or qualified healthcare provider. Feedback welcome to wiki-feedback@rosacea-research.org
Arachidonic Acid is responsible for the production of a pro-inflammatory series of prostaglandins and thromboxanes through the cycloxygenase (COX) pathway, and these prostaglandins and thromboxanes, along with leukotrienes from the 5-lipoxygenase (5-LOX) pathway, play a role in making the blood vessels dilated and leaky:
http://www.cvphysiology.com/Blood%20Flow/BF013.htm
The COX enzyme really exists as two different isoforms: COX-1 and COX-2, and Aspirin and other NSAIDS such as Ibuprofen block both isoforms, although slightly differently. While several new selective COX-2 inhibitors have recently been linked with heart attacks, probably due to their tendency to downregulate COX-2 prostaglandins in comparison to COX-1 thromboxanes, Aspirin and other NSAIDs are considered relatively safe.
Many rosaceans have found that Aspirin, in particular, can help to minimize the flushing and burning associated with the disease.
See Also:
Useful links:
