COX Inhibitors

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White Willow Trees Contain Salicin

Arachidonic Acid is responsible for the production of a pro-inflammatory series of prostaglandins and thromboxanes through the cycloxygenase (COX) pathway, and these prostaglandins and thromboxanes, along with leukotrienes from the 5-lipoxygenase (5-LOX) pathway, play a role in making the blood vessels dilated and leaky:

The COX enzyme really exists as two different isoforms: COX-1 and COX-2, and Aspirin and other NSAIDS such as Ibuprofen block both isoforms, although slightly differently. While several new selective COX-2 inhibitors have recently been linked with heart attacks, probably due to their tendency to downregulate COX-2 prostaglandins in comparison to COX-1 thromboxanes, Aspirin and other NSAIDs are considered relatively safe.

Many rosaceans have found that Aspirin, in particular, can help to minimize the flushing and burning associated with the disease.

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