Dual COX & 5-LOX Inhibitors

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These pages hold in-progress web pages for the benefit of Rosacea Support Group members. Information provided herein is intended for informational purposes only and is not intended to replace medical advice offered by a physician or qualified healthcare provider. Feedback welcome to wiki-feedback@rosacea-research.org




Mangos contain quercetin

Arachidonic Acid is responsible for the production of a pro-inflammatory series of prostaglandins and thromboxanes through the cycloxygenase pathway (COX), and these prostaglandins and thromboxanes along with leukotrienes from the 5-lipoxygenase (5-LOX) pathway play a role in making the blood vessels dilated and leaky: Arachidonic Acid Metabolites

And the leukotrienes in particular play a major role in inflammation:The Role of Leukotrienes in Inflammation

Inhibiting both the COX and 5-LOX pathways should therefore help decrease the inflammation associated with rosacea, although those who are sensitive to Aspirin, NSAIDs and natural salicylates may find that inhibiting the COX pathway may cause additional triggering of their rosacea.


Some dual COX and 5-LOX inhibitors are:



Useful links: