Isotretinoin
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Isotretinoin is a prescription retinoid, derived from Vitamin A. While its method of action is not completely understood, studies suggest it has an anti-inflammatory action, reduces sebum production, and shrinks sebaceous glands. Studies also suggest that low dose isotretinoin treatment can help control rosacea symptoms. However, due to links to birth defects and possible links to increased depression and suicide, in some countries it is becoming increasingly difficult to obtain a prescription for isotretinoin.
Useful links:
- DermNet NZ: Isotretinoin
- accutane and matrix metalloproteinases (MMP) Matrix metalloproteinases of epithelial origin in facial sebum of patients with acne and their regulation by isotretinoin
- focus on low-dose accutane Efficacy of Low-Dose Isotretinoin in Patients With Treatment-Resistant Rosacea
- long term extra low dose accutane Continuous 'microdose' isotretinoin in adult recalcitrant rosacea
- FDA Alert: Isotretinoin (marketed as Accutane) Capsule Information
- No association found between patients receiving isotretinoin for acne and the development of depression in a Canadian prospective cohort
- http://www.drugs.com/MTM/isotretinoin.html
