Zileuton
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Zileuton, a prescription 5-LOX inhibitor (see 5-LOX Inhibitors) used to treat asthma, has been shown in one study to reduce the number of inflammatory lesions and decrease sebum production in people with acne:
zileuton reduces sebum production Zileuton, an Oral 5-Lipoxygenase Inhibitor, Directly Reduces Sebum Production
However, another study in acne showed Zileuton had no better effect than placebo:
Zileuton disappoints for acne relief, rosacea hopes dashed also ? Press Release
Still, through its ability to inhibit the production of a host of pro-inflammatory leukotrienes, Zileuton may provide some relief for rosaceans. Only a controlled study of Zileuton specifically for rosacea will tell.
