Difference between revisions of "5-LOX Inhibitors"

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Inhibiting the 5-LOX pathway prevents the production of these pro-inflammatory leukotrienes and seems to help alleviate many of the symptoms associated with inflammation and allergy.
 
Inhibiting the 5-LOX pathway prevents the production of these pro-inflammatory leukotrienes and seems to help alleviate many of the symptoms associated with inflammation and allergy.
  
As a warning, since leukotrienes are part of the immune response, inhibiting 5-LOX and the downstream leukotrienes could actually cause a decrease in immune functioning and an increase in parasitic burdens.  Here's a study which suggests this possibility and another discussing the feedback loop that exists between the downstream Leukotriene B4 (LTB4) and the antimicrobial peptide cathelicidin (LL-37):
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As a warning, since leukotrienes are part of the immune response, inhibiting 5-LOX and the downstream leukotrienes could actually cause a decrease in immune functioning and an increase in parasitic burdens:
  
 
[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16148135&query_hl=10 Leukotrienes play a role in the control of parasite burden in murine strongyloidiasis.]
 
[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16148135&query_hl=10 Leukotrienes play a role in the control of parasite burden in murine strongyloidiasis.]
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[http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17347013&ordinalpos=45&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum Inhibition of leukotriene biosynthesis abrogates the host control of Mycobacterium tuberculosis.]
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Here's a study which suggests this possibility and another discussing the feedback loop that exists between the downstream Leukotriene B4 (LTB4) and the antimicrobial peptide cathelicidin (LL-37):
 +
  
 
[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17446260&query_hl=61&itool=pubmed_docsum  Leukotriene B4 triggers release of the cathelicidin LL-37 from human neutrophils: novel lipid-peptide interactions in innate immune responses]  
 
[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17446260&query_hl=61&itool=pubmed_docsum  Leukotriene B4 triggers release of the cathelicidin LL-37 from human neutrophils: novel lipid-peptide interactions in innate immune responses]  

Revision as of 21:43, 9 December 2007

Welcome to the

Rosacea Support Resource Pages

These pages hold in-progress web pages for the benefit of Rosacea Support Group members. Information provided herein is intended for informational purposes only and is not intended to replace medical advice offered by a physician or qualified healthcare provider. Feedback welcome to wiki-feedback@rosacea-research.org



Allergen & Pseudo-Allergen

Arachidonic Acid is responsible for the production of a pro-inflammatory series of leukotrienes through the 5-lipoxygenase (5-LOX) pathway, and these leukotrienes along with the prostaglandins and thromboxanes from the cycloxygenase (COX) pathway play a major role in inflammation:

The Role of Leukotrienes in Inflammation

Inhibiting the 5-LOX pathway prevents the production of these pro-inflammatory leukotrienes and seems to help alleviate many of the symptoms associated with inflammation and allergy.

As a warning, since leukotrienes are part of the immune response, inhibiting 5-LOX and the downstream leukotrienes could actually cause a decrease in immune functioning and an increase in parasitic burdens:

Leukotrienes play a role in the control of parasite burden in murine strongyloidiasis.

Inhibition of leukotriene biosynthesis abrogates the host control of Mycobacterium tuberculosis.

Here's a study which suggests this possibility and another discussing the feedback loop that exists between the downstream Leukotriene B4 (LTB4) and the antimicrobial peptide cathelicidin (LL-37):


Leukotriene B4 triggers release of the cathelicidin LL-37 from human neutrophils: novel lipid-peptide interactions in innate immune responses

Of course, there could be other explanations for this, but caution is warranted when using 5-LOX inhibitors, just as caution is warranted with COX inhibitors (including Aspirin).


Some 5-LOX inhibitors are:


Useful links:

http://www.usenet.com/newsgroups/sci.cryonics/msg00081.html